For Researchers

518px Axial DIR MRI of a brain with multiple sclerosis lesionsScientists throughout the world depend on the Rocky Mountain MS Center Tissue Bank to supply brain and spinal cord samples to support their research. We’ve distributed specimens to hundreds of investigators worldwide, and thousands of people have consented to be donors after death.

Since 1976 the scientific studies conducted with Rocky Mountain MS Center tissue samples have led to several key discoveries, and researchers using tissue bank materials have produced more than 150 published articles and reports. See below for a partial list of those publications.

To request tissue, please Click here for a tissue request form and contact:

Tissue Bank Coordinator
12700 E 19th ave, Rm 5420D
Aurora, CO 80045
720-626-6060 CELL
303-724-6012 FAX
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1: Vyshkina T,Kalman B.  Haplotypes within genes of beta-chemokines in 17 q 11 are associated with multiple sclerosis: a second phase study. Hum Genet. 2005;3:1-9 [Epub ahead of  print]

2: Banisor I, Leist TP, Kalman B. Involvement of beta-chemokines in the development of inflammatory demyelination. J Neuroinflammation. 2005;24 (2):7.

3: Vyshkina T, Banisor I, Shugart YY, Leist TP, Kalman B. Genetic variants of Complex I in multiple sclerosis. J Neurol Sci. 2005;1:228(1):55-64.

4: Vyshkina T, Leist TP, Shugart YY, Kalman B. CD45 (PTPRC) as a candidate gene in multiple sclerosis. Mult Scler. 2004;10(6):614-7.

5: Vyshkina T, Shugart YY, Birnbaum G, Leist TP, Kalman B. Association of haplotypes in the beta-chemokine locus with multiple sclerosis. Eur J Hum Genet. 2005;13(2):240-7.

6: Kalman B, Lyist TP. Familial multiple sclerosis and other inherited disorders of the white matter. Neurologist. 2004;1O(4):201-15. Review.

7: Bizzozero, O.A., DeJesus, G., and Bixler, H, and Pastuszyn, A. (2005) Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis. Neurochemical Res 30,139-149. 

8: Bizzozero OA, Dejesus G, Callahan K, Pastuszyn A. 2005. Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis. J Neurosci Res 81: 687-695.

9: Sriram S., Ljunggren-Rose A., Yao SY, Whetsall,W.  Detection of Chlamydial Bodies and Antigens in the Central Nervous System of Patients with Multiple Sclerosis.  J Infectious Diseases  2005; 192: 1219-28

10. David Wheeler, Peter Calabresi, Avindra Nath and Norman Haughey.  Alteration in the Lipid Composition of Normal Appearing Brain Tissue in Multiple Sclerosis Patients. abstract presented at the 7th international symposium on Neurovirology - May 30-June6.  Doubletree hotel.  Philadelphia Pennsylvania

11. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.  Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX. Brain 2007 Feb;130(Pt 2):490-501

12. Major cytoskeletal proteins are carbonylated in multiple sclerosis. Bizzozero OA. ISN satellite meeting on “Myelin development and function,” Aug 15-19, 2007, Chichen Itza, Mexico. p. 33

13. Fast Multi-Slice Mapping of the Myelin Water Fraction Using Multi-Compartment Analysis of T2* Decay at 3 Tesla – A Preliminary Post-Mortem Study.  Du YP, Chu R, Hwang D, Brown MS, Kleinschmidt-DeMasters BK, Simon J.  Proceedings of the 14th Annual Meeting of ISMRM, Seattle, 2006.

14. Blokhin A,  Vyshkina T, Komoly S, Kalman B.  Lack of mitochondrial DNA deletions in lesions of multiple sclerosis.  Neuromolec Med 2008;10:187-94. PMID: 18286391 

15. Blokhin A, Vyshkina T, Komoly S, Kalman B.  Variations in mitochondrial DNA copy numbers in MS brains.  J Mol Neurosci 2008;35:283-7. PMID: 18566918

16. Qin J,  Goswami R, Balabanov R, Dawson G. Oxidized phosphatidylcholine (OxPC) is a marker for neurodegeneration multiple sclerosis brain .J. Neurosci Res;2007;85:977-984.

17. Qin J, Goswami R, Dawson S, Dawson G. Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress. J Neurosci Res 2008;86:2414-2422

18. Wheeler D, Venkata V, Bandaru R, Calabresi PA, et al.  A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis.  Brain;2008 Sep 4 [Epub ahead of print]  PMID: 18772223

19. Kim SJ, Peng J, Welsh CJ, Li J. Ceramide potentiates inflammatory destruction of oligodendrocytes.  Abstract;Soc for Neurosci; 2008.